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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in grown-ups with a body mass index (BMI) of greater than 27, provided that they also experience weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes established that patients had a typical weight loss of four years old.1% instead of participants who have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at 12 months. Using two separate drugs to shed weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight-loss and the those who go through it you should err to the side of caution and allow FDA do its job and demand some study be done in order that the public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on their own medications. Researchers found out that participants using this drug to get a year, dropped a few pounds within 4 weeks and have kept the load off through the entire 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them more efficient and safer. Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that since right now there are no long term prescription slimming capsules that have been licensed by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug may also raise hypertension and heartbeat, and shouldn't be used in people with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients on the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. Other people who should not use Contrave are patients experiencing bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave shouldn't be prescribed for females who are pregnant or looking to become pregnant.